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KMID : 1140120060110040305
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Cancer Prevention Research
2006 Volume.11 No. 4 p.305 ~ p.310
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A Study on the Gene Expression Patterns of Bisphenol A-exposed Nematode (Caenorhabditis elegans)
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Lee Chul-Woo
Hwang Jeong-Won
Jung Hwa-Jin
Kim Eun-Kyoung
Kim Hyun-Mi
Chung Young-Hee
Choi Kyung-Hee
Seo Young-Rok
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Abstract
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Endocrine disruptors are potentially linked to decreases in fertility as well as increases in some types of cancers throughout the animals including humans. Recently, soil-dwelling nematode Caenorhabditis elegans (C. elegans) has been used to monitor the toxicity of endocrine disruptors. In this study, changes in gene expression in C. elegans in response to endocrine disruptor bisphenol A were investigated with a microarray consisting of the nematode-specific cDNA probes. Upon exposure to bisphenol A for 24 hrs, we found 26 different genes that were up- or down-regulated with statistically significant changes. Cytochrome P450 and phosphatse genes were up-regulated, however, heat shock protein, collagen and annexin were down-regulated. Compared to classical tests this C. elegans chip microarray will be useful
in generating gene expression profiles at the same time and be used for well regulated biomarker genes to study of toxicogenomics more in detail.
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KEYWORD
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Nematode, Caenorhabditis elegans, Microarray, Bisphenol A
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